Darwin at Down: It is 1849 and Charles Darwin is in the beginning stages of his famous book, "On the Origin of the Species". Egged on by his colleague Joseph Hooker, Darwin is afraid of being scooped by other scientists working on the same problem. He knows that this work will change scientific inquiry forever. But his wife is afraid that God will smite Darwin and his family for publishing such a controversial theory. When Annie, Darwin's young daughter, contracts a serious illness, Charles begins to wonder if publishing these theories is worth the ultimate cost. Will he lose his marriage? His children? If we challenge the natural order of the Universe, will God exact his revenge?